Synthesis and Pharmacology of a Noncompetitive Antagonist of Angiotensin- Induced Contractions of Vascular Smooth Muscle [SarcosylJ^Cysteinyl (S-Methyl)]-Angiotensin II
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چکیده
Limas CJ, Cohn JN (1974) Stimulation of vascular smooth muscle Na-K ATPase by vasodilators. Circ Res 35: 601-607 Messina EJ, Weiner R, Kaley G (1976) Prostaglandins and local circulatory control. Fed Proc 35: 2367-2375 Schwartz A, Lindenmeyer GE, Allen JC (1975) The sodiumpotassium adenosine triphosphatase: Pharmacological, physiological, and biochemical aspects. Pharmacol Rev 27: 3-134 Somlyo AP, Somlyo AV, Smiesko V (1972) Cyclic AMP and vascular smooth muscle. Am J Physiol 213: 725-733 Strong CG, Bohr DF (1974) Effects of prostaglandins Ei, E2, Ai, and Fi,, on isolated vascular smooth muscle. Am J Physiol 213: 725-733 Toda N (1974) Responsiveness to potassium and calcium ions of isolated cerebral arteries. Am J Physiol 227: 1206-1211 Webb R, Bohr DF (1978) Potassium induced relaxation as an indicator of Na-K ATPase activity in vascular smooth muscle. Blood Vessels 15: 198-207 Weiner R, Messina EJ, Rodenberg J, Kaley G (1977) Indomethacin reduces skeletal muscle vasodilation induced by exercise and ischemia. Artery 3: 52-58
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Synthesis and pharmacology of a noncompetitive antagonist of angiotensin-induced contractions of vascular smooth muscle. [Sarcosyl]1-[cysteinyl (s-methyl)]8-angiotensin II.
The synthesis of an angiotensin II (A II) antagonist, sarcosyl1-cysteinyl(S-methyl)8-angiotensin II [Sar1-Cys(Me)8-A II], showing partial organ selectivity and properties of a noncompetitive antagonist, is described. The compound was found to be an extremely potent antagonist on vascular smooth muscle both in vitro (pA2 for rabbit aorta approximately equal to 9.2) and in vivo on rat blood press...
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